With huge help of my sister here is a short guide for Prague. Interesting galleries, shops and good restaurants. Lets start with galleries...


GALLERIES:
DOX- Centre of Contemporary Art, modern art, large rooftop terrace, 10 min from city centre, (small Tate Modern)
Museum Kampa - renovated old mill, literally few steps from Charles Bridge, right in the heart of the city, beautiful walk by river, modern art, permanent exhibition of Frantisek Kupka and loads more
more links -
Galerie Rudolfinum , Czech Design, City Gallery Prague

SHOPS:
Futurista - great selection of Czech Design, ( from earrings to furniture) blogged about this shop before,
must visit!
Kubista - contemporary Czech Design
Botas - trainers lover?, old Czech classic
Papelote - paper goodies

more links:
http://codemode.cz/
http://www.juliusfashion.com/
RESTAURANTS:
Ambiente - Czech modern kitchen
Cafe Savoy
Cestr - brand new restaurant, Czech kitchen
Potrefena Husa - chain of very good puby restaurants, great food, beer menus etc.

Very cool, secret restaurant :)...
Avion 58
vegetarian -
Maitrea , Lehka Hlava
top ten restaurants in Prague -
here


more
good restaurants here
MUSIC, DANCE:
+ there is loads of jazz clubs in centre of Prague
Cinemas :
art cinemas, English
If you are planning to visit another parts, towns in Czech I recommend :
Cesky Krumlov
Marianske Lazne
Kutna Hora
.................and there is so much more...but I hope this can help a bit
Have a good weekend!